Acute Interstitial Nephritis Induced by Citrullus Colocynthis

Acute interstitial nephritis (AIN) is known as a common cause of acute kidney injury, found in 15% to 27% of kidney biopsies. Drug-induced AIN is currently the most common cause of AIN. The most common medications causing AIN are antibiotics and nonsteroidal anti-inflammatory drugs. We describe a ca...

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Bibliographic Details
Published inIranian journal of kidney diseases Vol. 11; no. 5; p. 385
Main Authors Savaj, Shokoufeh, Ghaffari, Mohammad, Abbasi, Mohammad Amin, Azar, Javad
Format Journal Article
LanguageEnglish
Published Iran Iranian Society of Nephrology 01.09.2017
Subjects
Acute Disease
Adult
Citrullus colocynthis - chemistry
Diabetes
Female
Health risk assessment
Humans
Kidney - drug effects
Kidney - pathology
Nephritis, Interstitial - chemically induced
Nephritis, Interstitial - pathology
Nephritis, Interstitial - therapy
Plant Extracts - adverse effects
Renal Dialysis
Weight Loss - drug effects
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Summary:Acute interstitial nephritis (AIN) is known as a common cause of acute kidney injury, found in 15% to 27% of kidney biopsies. Drug-induced AIN is currently the most common cause of AIN. The most common medications causing AIN are antibiotics and nonsteroidal anti-inflammatory drugs. We describe a case of Citrullus colocynthis (herbal remedy for diabetes mellitus and weight reduction) that induced AIN. A 31-year-old woman with major thalassemia, diabetes mellitus, and hepatitis C infection was admitted because of flank pain and unexpected increase in serum creatinine level. She had been using Citrullus colocynthis for 3 months. Kidney biopsy results suggested AIN. She did not respond to steroid therapy and underwent hemodialysis. We suggest the use of Citrullus colocynthis as a herbal medicine with extreme caution.
ISSN:1735-8582
1735-8604