Fresh venous femoral autografts and allografts as carotid substitutes in matched dogs from the same litter

Pathological and biochemical investigations were performed on femoral veins used as fresh autografts and allograft substitutes in the carotid arteries of dogs from the same litter and separated in two groups described as compatible and incompatible after a mixed leukocyte culture (MLC). After 5 mont...

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Bibliographic Details
Published inJournal of cardiovascular surgery Vol. 31; no. 2; p. 147
Main Authors Merhi, Y, Roy, R, Douville, Y, Ben-Slimane, S, Guzman, R, Downs, A, Hébert, J, Roy, P E, Guidoin, R
Format Journal Article
LanguageEnglish
Published Italy 01.03.1990
Subjects
6-Ketoprostaglandin F1 alpha - analysis
Animals
Blood Vessel Prosthesis
Carotid Arteries - surgery
Dogs
Female
Femoral Vein - transplantation
Graft Survival
Histocompatibility Testing
Male
Microscopy, Electron, Scanning
Thromboxane B2 - analysis
Time Factors
Transplantation, Autologous
Transplantation, Homologous
Vascular Patency
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Summary:Pathological and biochemical investigations were performed on femoral veins used as fresh autografts and allograft substitutes in the carotid arteries of dogs from the same litter and separated in two groups described as compatible and incompatible after a mixed leukocyte culture (MLC). After 5 months of implantation, all the arterial substitutes were patent. The analyses gave the following results: 1. The haematologic parameters were not affected by the grafts. 2. Light microscopy (LM) and scanning electron microscopy (SEM) indicate a thrombotic accumulation and the presence of inflammatory cells in the compatible and the incompatible allografts. The occurrence of pathological changes was more pronounced in the incompatible group. 3. Immunostaining of anti-factor VIII-related antigen reveals a better preservation of the endothelial cell wall on the autograft. 4. The 6-keto-PGF1 alpha/TXB2 ratios of the autografts and the compatible allografts were similar.
ISSN:0021-9509