Inhibition of extracellular matrix-degrading endopeptidases: problems, comments, and hypotheses

A critical analysis of research on inhibitors of extracellular matrix-degrading endopeptidases reveals that a great number of substances could potentially be used for therapeutic purposes. There are, however, many obstacles that hinder this objective. If the problems are due to the characteristics o...

Full description

Saved in:
Bibliographic Details
Published inBiological chemistry Vol. 379; no. 8-9; pp. 1007 - 1018
Main Author Baici, A
Format Journal Article
LanguageEnglish
Published Germany 01.08.1998
Subjects
Animals
Endopeptidases - metabolism
Extracellular Matrix - metabolism
Humans
Hydrolysis
Kinetics
Substrate Specificity
Online AccessGet full text

Cover

More Information
Summary:A critical analysis of research on inhibitors of extracellular matrix-degrading endopeptidases reveals that a great number of substances could potentially be used for therapeutic purposes. There are, however, many obstacles that hinder this objective. If the problems are due to the characteristics of the inhibitors, they can possibly be circumvented by chemical methods, but if they are innate properties of the pathological environment and of the mode of action of the enzymes, the problem may not have an immediate solution.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1431-6730