Intraperitoneal cisplatin--mitoxantrone in ovarian cancer patients with minimal residual disease

A phase II trial was conducted to further explore the potential of salvage intraperitoneal (IP) cisplatin-based therapy in patients with residual ovarian cancer. Twenty-five patients were treated with a regimen of cisplatin (75 mg/m2) and mitoxantrone (15 mg/m2) delivered IP every three weeks for a...

Full description

Saved in:
Bibliographic Details
Published inEuropean journal of gynaecological oncology Vol. 18; no. 1; p. 71
Main Authors Topuz, E, Aydiner, A, Saip, P, Bengisu, E, Berkman, S, Disci, R
Format Journal Article
LanguageEnglish
Published Italy 1997
Subjects
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols - administration & dosage
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Cisplatin - administration & dosage
Female
Humans
Middle Aged
Mitoxantrone - administration & dosage
Neoplasm, Residual
Ovarian Neoplasms - drug therapy
Peritoneal Cavity
Salvage Therapy
Online AccessGet more information

Cover

More Information
Summary:A phase II trial was conducted to further explore the potential of salvage intraperitoneal (IP) cisplatin-based therapy in patients with residual ovarian cancer. Twenty-five patients were treated with a regimen of cisplatin (75 mg/m2) and mitoxantrone (15 mg/m2) delivered IP every three weeks for a maximum of six cycles. Ten patients achieved a pathologically complete response (pCR) and six were clinically stable without evidence of disease. After a median follow-up of 18 months, the median progression-free survival (PFS) was 16 months (95% confidence interval-CI-3-29%). The actuarial PFS at 24 months was 36% (95% CI 13-59). Overall eight out of 25 patients (32%) had an IP relapse and thus were considered as local treatment failures. The major toxic side effects were nausea, vomiting, abdominal pain and renal toxicity. Future trials exploring IP delivery of these drugs should attempt to optimize drug dose and schedule and subset analysis of clinical studies should help in identifying patients who are particularly sensitive to this therapeutic approach.
ISSN:0392-2936