Atrial natriuretic peptide secretion in heart transplant patients

Plasma atrial natriuretic peptide (ANP), plasma renin activity (PRA), aldosterone (ALD) and vasopressin (VP) were assessed in six heart transplant patients (HTP) and ten healthy subjects under bed rest conditions and 60 and 120 minutes after head-out water immersion (WI). Bed rest had no significant...

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Bibliographic Details
Published inInternational journal of artificial organs Vol. 12; no. 5; p. 321
Main Authors Kokot, F, Religa, Z, Pasyk, S, Wiecek, A, Frycz, J, Grzeszczak, W, Bochenek, A, Dulawa, J
Format Journal Article
LanguageEnglish
Published United States 01.05.1989
Subjects
Adult
Aldosterone - secretion
Atrial Natriuretic Factor - secretion
Heart Transplantation
Humans
Immersion
Male
Plasma Volume
Renin - secretion
Vasopressins - secretion
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Summary:Plasma atrial natriuretic peptide (ANP), plasma renin activity (PRA), aldosterone (ALD) and vasopressin (VP) were assessed in six heart transplant patients (HTP) and ten healthy subjects under bed rest conditions and 60 and 120 minutes after head-out water immersion (WI). Bed rest had no significant influence on these parameters. WI raised plasma volume (PV) to the same extent in both groups. This increase of PV was accompanied by significant suppression of PRA, ALD and VP and an increase of plasma ANP. In HTP basal plasma ANP was significantly elevated and the ANP response to central hypervolemia reduced. Significantly elevated VP plasma levels were also found in HTP. These endocrine abnormalities in HTP seem to be caused by latent failure of the transplanted heart. No direct correlation was found between plasma ANP and PRA, ALD and VP under basal conditions and after WI in either HTP or normals.
ISSN:0391-3988