Unique HLA-D region heterogeneity in American blacks

American blacks and whites show heterogeneity in serologically detected and lymphocyte-defined HLA-D region antigen frequencies. Also, alterations in linkage relationships are seen in DR and DQ specificities. Since homozygous typing cells probably identify a cluster of specificities that are usually...

Full description

Saved in:
Bibliographic Details
Published inTransplantation proceedings Vol. 19; no. 1 Pt 1; p. 870
Main Authors Dunston, G M, Hurley, C K, Hartzman, R J, Johnson, A H
Format Journal Article
LanguageEnglish
Published United States 01.02.1987
Subjects
Black or African American
Black People - genetics
DNA Probes
Histocompatibility Testing
HLA-D Antigens - genetics
HLA-DQ Antigens - genetics
HLA-DR Antigens - genetics
HLA-DR Serological Subtypes
Humans
United States
United States
Online AccessGet more information

Cover

More Information
Summary:American blacks and whites show heterogeneity in serologically detected and lymphocyte-defined HLA-D region antigen frequencies. Also, alterations in linkage relationships are seen in DR and DQ specificities. Since homozygous typing cells probably identify a cluster of specificities that are usually found in linkage disequilibrium in a given population, it is not surprising that blacks have unique HLA-D types. The significance of the observed differences in the function of class II molecules is being investigated.
ISSN:0041-1345