Derivatives of 2-N-arylalkylamino-2-methyl-1-propanol with antiarrhythmic activity

Several aryl derivatives of achiral 2-amino-2-methyl-1-propanol have been obtained and tested for prophylactic and curative activity in different types of experimental arrhythmia. Interesting results were obtained for compounds 3 and 4 with activity and toxicity similar to those of quinidine.

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Bibliographic Details
Published inPolish journal of pharmacology and pharmacy Vol. 38; no. 2; p. 215
Main Authors Eckstein, M, Zajaczkowska, J, Krupińska, J, Michna, M
Format Journal Article
LanguageEnglish
Published Poland 01.03.1986
Subjects
Animals
Anti-Arrhythmia Agents - chemical synthesis
Anti-Arrhythmia Agents - toxicity
Arrhythmias, Cardiac - chemically induced
Arrhythmias, Cardiac - prevention & control
Guinea Pigs
Male
Mice
Propanolamines - chemical synthesis
Propanolamines - pharmacology
Propanolamines - toxicity
Rats
Rats, Inbred Strains
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Summary:Several aryl derivatives of achiral 2-amino-2-methyl-1-propanol have been obtained and tested for prophylactic and curative activity in different types of experimental arrhythmia. Interesting results were obtained for compounds 3 and 4 with activity and toxicity similar to those of quinidine.
ISSN:0301-0244