Differences in hepatic pathology resulting from bile duct obstruction in young and old rats

1. Young and adult rats subjected to complete bile duct ligation from 4 to 40 days revealed different liver histopathologies at the end of the experimental period. 2. In young rats, ductal and ductular proliferation resulted in septal fibrosis which, originating from the portal spaces, tended to del...

Full description

Saved in:
Bibliographic Details
Published inBrazilian journal of medical and biological research Vol. 21; no. 1; pp. 75 - 83
Main Authors Medeiros, M V, Freitas, L A, Andrade, Z A
Format Journal Article
LanguageEnglish
Published Brazil 1988
Subjects
Age Factors
Animals
Cholestasis - pathology
Common Bile Duct - pathology
Female
Karyometry
Ligation
Liver - ultrastructure
Male
Microscopy, Electron
Rats
Rats, Inbred Strains
Online AccessGet full text

Cover

More Information
Summary:1. Young and adult rats subjected to complete bile duct ligation from 4 to 40 days revealed different liver histopathologies at the end of the experimental period. 2. In young rats, ductal and ductular proliferation resulted in septal fibrosis which, originating from the portal spaces, tended to delimit areas of nodular parenchymal transformation (secondary biliary cirrhosis). In adult rats, proliferating ductal and ductular structures diffusely invaded the hepatic parenchyma, dissociating the liver cell plates in a pattern similar to that of a malignant neoplastic growth. 3. The different result of the lesions in young and old rats suggests that an age-related factor may be involved in the pathogenesis of lesions resulting from biliary obstruction.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0100-879X
1414-431X