Effects of Piper sp extract on pregnancy in rats

Abortive effects on cattle have been attributed to Piper sp, popularly called Pariparoba. In the present study we tested the possible toxicity of this plant by analyzing gestational outcome parameters in female rats given 300 mg/kg of an aqueous extract of Piper sp leaves and stalks per os, daily, b...

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Published inBrazilian journal of medical and biological research Vol. 21; no. 1; pp. 111 - 113
Main Authors Schneid, E S, Obelar, E, Colares, M I, Rodegheri, V J, Bizzotto, J H, Battastini, A M, Baisch, A L, De Almeida, T R, Amarante Silva, F, Sinnott Silva, E
Format Journal Article
LanguageEnglish
Published Brazil 1988
Subjects
Abortion, Spontaneous - chemically induced
Animals
Brazil
Female
Plant Extracts - toxicity
Plants, Medicinal
Pregnancy
Rats
Rats, Inbred Strains
Brazil
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Summary:Abortive effects on cattle have been attributed to Piper sp, popularly called Pariparoba. In the present study we tested the possible toxicity of this plant by analyzing gestational outcome parameters in female rats given 300 mg/kg of an aqueous extract of Piper sp leaves and stalks per os, daily, between the 9th and the 21st day of pregnancy. The animals were killed just before delivery and the following features were observed: numbers of corpora albicantia, fetuses and reabsorptions; weights of fetuses, placentae and fetal membranes; fetal sex and the presence of overt malformations in fetuses; and implantation and reabsorption indices. No significant differences were detected between control and treated groups. The results suggest that Piper sp does not modify gestational outcome in rats.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:0100-879X