Monoclonal rat anti-MHC alloantibodies detect HLA-linked polymorphisms in humans

Two monoclonal rat anti-MHC alloantibodies detect a polymorphic determinant expressed on the peripheral lymphocytes of normal human donors. The pattern of cytotoxicity observed with these antibodies correlated with the HLA type of the individual; no HLA-A-locus specificities showed significant assoc...

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Bibliographic Details
Published inImmunogenetics (New York) Vol. 12; no. 3-4; p. 313
Main Authors Boyd, H C, Smilek, D E, Spielman, R S, Zmijewski, C M, McKearn, T J
Format Journal Article
LanguageEnglish
Published United States 01.01.1981
Subjects
Animals
Clone Cells - immunology
Genetic Linkage
HLA Antigens - genetics
HLA Antigens - immunology
Humans
Isoantibodies - immunology
Lod Score
Lymphocytes - immunology
Major Histocompatibility Complex
Mice
Pedigree
Polymorphism, Genetic
Rabbits
Rats
Rats, Inbred BN
Rats, Inbred Lew
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Summary:Two monoclonal rat anti-MHC alloantibodies detect a polymorphic determinant expressed on the peripheral lymphocytes of normal human donors. The pattern of cytotoxicity observed with these antibodies correlated with the HLA type of the individual; no HLA-A-locus specificities showed significant associations, and all of the HLA-B-locus specificities showing significant association were members of the Bw6 supertype. Family studies established that the determinant detected by the monoclonal antibodies is linked to HLA. These studies therefore provide an alternative basis for the production of monoclonal antibodies to polymorphic HLA determinants based on the conservation of polymorphic MHC determinants between man and rats.
ISSN:0093-7711
DOI:10.1007/BF01561673