Transient alteration of theophylline half-life: possible association with Herpes simplex infection

Transient alteration of theophylline half-life resulting in theophylline neurotoxicity is reported in a nine-year-old child. The alteration in theophylline elimination half-life was associated with Herpes simplex gingivostomatitis. This association has not previously been demonstrated. The report is...

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Bibliographic Details
Published inAnnals of allergy Vol. 49; no. 2; p. 109
Main Authors Anolik, R, Kolski, G B, Schaible, D H, Ratner, J
Format Journal Article
LanguageEnglish
Published United States 01.08.1982
Subjects
Asthma - metabolism
Child
Half-Life
Humans
Male
Stomatitis, Herpetic - metabolism
Theophylline - metabolism
Theophylline - toxicity
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Summary:Transient alteration of theophylline half-life resulting in theophylline neurotoxicity is reported in a nine-year-old child. The alteration in theophylline elimination half-life was associated with Herpes simplex gingivostomatitis. This association has not previously been demonstrated. The report is contrasted with a study of theophylline clearance variability in children.
ISSN:0003-4738