Effect of oral calcium and vitamin D on glucocorticoid-induced osteopenia

Bone-loss in glucocorticoid-induced osteopenia is most evident in trabecular bone such as the vertebrae. Bone mineral content (BMC) measurements of the spine were prospectively studied, comparing the preventive effect of calcium (500 mg a day) and calcium plus Vitamin D (4000 IU on alternate days) d...

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Bibliographic Details
Published inClinical and experimental rheumatology Vol. 6; no. 2; p. 113
Main Authors Bijlsma, J W, Raymakers, J A, Mosch, C, Hoekstra, A, Derksen, R H, Baart de la Faille, H, Duursma, S A
Format Journal Article
LanguageEnglish
Published Italy 01.04.1988
Subjects
Administration, Oral
Adult
Aged
Bone Diseases, Metabolic - chemically induced
Bone Diseases, Metabolic - drug therapy
Calcium - administration & dosage
Calcium - pharmacology
Calcium - therapeutic use
Female
Glucocorticoids - adverse effects
Humans
Male
Middle Aged
Prednisone - therapeutic use
Vitamin D - administration & dosage
Vitamin D - pharmacology
Vitamin D - therapeutic use
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Summary:Bone-loss in glucocorticoid-induced osteopenia is most evident in trabecular bone such as the vertebrae. Bone mineral content (BMC) measurements of the spine were prospectively studied, comparing the preventive effect of calcium (500 mg a day) and calcium plus Vitamin D (4000 IU on alternate days) during long-term corticosteroid treatment. A small increase in BMC was noted in both groups, but no differences between preventive calcium and calcium plus Vitamin D became evident. It is suggested that patients who are receiving prednisone should be advised to use supplemental calcium.
ISSN:0392-856X