Quantitative aspects of the fever response elicited by intracerebral injection of endotoxin in the guinea-pig

Fever developing after intracerebral injections of lipopolysaccharide (LPS) to guinea-pigs were monophasic, with only one peak of inner body temperature slowly developing and longlasting in a dose range 20 to 200 ng of LPS. Latency time was inversely related to the dose of LPS. Indomethacin injected...

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Bibliographic Details
Published inPhysiological research Vol. 41; no. 1; pp. 63 - 64
Main Authors Spízková, K, Stefl, B
Format Journal Article
LanguageEnglish
Published Czech Republic 1992
Subjects
Analysis of Variance
Animals
Endotoxins - administration & dosage
Endotoxins - pharmacology
Fever - chemically induced
Fever - physiopathology
Guinea Pigs
Indomethacin - pharmacology
Injections
Lipopolysaccharides - administration & dosage
Male
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Summary:Fever developing after intracerebral injections of lipopolysaccharide (LPS) to guinea-pigs were monophasic, with only one peak of inner body temperature slowly developing and longlasting in a dose range 20 to 200 ng of LPS. Latency time was inversely related to the dose of LPS. Indomethacin injected to the third brain ventricle did not abolish fever response.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0862-8408