Energy demand of cardioplegically perfused human hearts

Human adult hearts with aortic valve disease (n = 20) and hypertrophic obstructive cardiomyopathy (n = 1) were perfused intraoperatively with cold histidine buffered Bretschneider solution. During a seven minute cardioplegic perfusion the temperature level, the electrolyte level, the resistance of t...

Full description

Saved in:
Bibliographic Details
Published inJournal of cardiovascular surgery Vol. 26; no. 6; p. 558
Main Authors Preusse, C J, Winter, J, Schulte, H D, Bircks, W
Format Journal Article
LanguageEnglish
Published Italy 01.11.1985
Subjects
Adult
Aged
Aortic Valve - metabolism
Aortic Valve - surgery
Cardiomyopathy, Hypertrophic - metabolism
Cardiomyopathy, Hypertrophic - surgery
Coronary Vessels - physiopathology
Electrolytes - metabolism
Energy Metabolism
Female
Heart Arrest, Induced - methods
Heart Valve Diseases - metabolism
Heart Valve Diseases - surgery
Humans
Male
Middle Aged
Myocardium - metabolism
Oxygen Consumption
Partial Pressure
Perfusion - methods
Time Factors
Vascular Resistance
Online AccessGet more information

Cover

More Information
Summary:Human adult hearts with aortic valve disease (n = 20) and hypertrophic obstructive cardiomyopathy (n = 1) were perfused intraoperatively with cold histidine buffered Bretschneider solution. During a seven minute cardioplegic perfusion the temperature level, the electrolyte level, the resistance of the left (LCA) and right coronary artery (RCA), and myocardial O2 consumption were analysed. Equilibration of K+ was terminated shortly after the start of the perfusion while Na+ equilibration lasted for about 5 minutes. Resistance of RCA did not change significantly, but that of the LCA was diminished significantly (p less than 0.025) within the perfusion period indicating a delayed washout of calcium from the extracellular space. Myocardial O2 consumption was reduced from 2.71 ml/min (1. minute) to 1.51 ml/min (4. minute) to 0.93 ml/min (7. minute) although the temperature had reached a low level after 3 minutes. The difference between 4. to 7. minutes is significant (p less than 0.001). By our results it is concluded that in adult hearts high-volume cardioplegic perfusion at a flow rate of 1 ml/min X gm at a perfusion pressure of 40 to 50 mmHg should be performed for at least 6 to 7 minutes to achieve a sufficient intra-ischemic myocardial protection.
ISSN:0021-9509