Experimental assessment of selected antimotion drugs

Space motion sickness (SMS) has been a perplexing problem in both the Soviet and U.S. manned space programs. Both the sensory conflict theory (neuronal signal mismatch) and the cephalad fluid shift concept explain the mechanism. This paper reviews the mechanism of action of various drugs that primar...

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Bibliographic Details
Published inAviation, space, and environmental medicine Vol. 55; no. 4; p. 281
Main Authors Matsnev, E I, Bodo, D
Format Journal Article
LanguageEnglish
Published United States 01.04.1984
Subjects
Adolescent
Adult
Aerospace Medicine
Cinnarizine - therapeutic use
Coriolis Force
Electrocardiography
Humans
Hungary
Male
Motion Sickness - drug therapy
Posture
Scopolamine Hydrobromide - therapeutic use
USSR
Vinca Alkaloids - therapeutic use
Hungary
USSR
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Summary:Space motion sickness (SMS) has been a perplexing problem in both the Soviet and U.S. manned space programs. Both the sensory conflict theory (neuronal signal mismatch) and the cephalad fluid shift concept explain the mechanism. This paper reviews the mechanism of action of various drugs that primarily affect brain blood flow or brain metabolism. In particular, Cavinton (apovincamic acid ethyl ester) has been used successfully in offsetting SMS in experimental test subjects.
ISSN:0095-6562