Serum cytokine levels in patients with neutropenia

Serum samples from 76 patients with neutropenia and 34 control subjects were analyzed for levels of granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, interleukin 1 alpha, and tumor necrosis factor beta. Clinical correlates and duration of neutropenia were deter...

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Bibliographic Details
Published inArchives of pathology & laboratory medicine (1976) Vol. 118; no. 12; p. 1193
Main Authors Greendyke, R M, Sharma, K, Gifford, F R
Format Journal Article
LanguageEnglish
Published United States 01.12.1994
Subjects
Adult
Aged
Cytokines - blood
Female
Granulocyte Colony-Stimulating Factor - blood
Granulocyte-Macrophage Colony-Stimulating Factor - blood
Humans
Interleukin-1 - blood
Leukocyte Count
Lymphotoxin-alpha - blood
Male
Middle Aged
Neutropenia - blood
Neutropenia - etiology
Receptor, Macrophage Colony-Stimulating Factor
Receptors, Granulocyte Colony-Stimulating Factor
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ISSN0003-9985

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Summary:Serum samples from 76 patients with neutropenia and 34 control subjects were analyzed for levels of granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, interleukin 1 alpha, and tumor necrosis factor beta. Clinical correlates and duration of neutropenia were determined insofar as possible. Systemic acute inflammatory disease was present in only two patients. In most cases, the neutropenia was considered idiopathic or medication related. Significantly elevated serum granulocyte colony-stimulating factor levels were found in the patient group, regardless of the apparent cause of the neutropenia. Increased levels of granulocyte-macrophage colony-stimulating factor, interleukin 1, and tumor necrosis factor were seen in only one patient with sepsis.
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ISSN:0003-9985