Sofosbuvir and Daclatsvir in Treatment of Hepatitis C Virus-related Membranoproliferative Glomerulonephritis With Cryoglobulinemia in a Patient With Hepatitis C Genotype 4

Direct antivirals showed dramatic response in hepatitis C virus (HCV) eradication, but their effect on extrahepatic manifestations is still unclear. A 49-year-old woman was referred to us suffering from lower limb edema and frothy urine. Renal biopsy was done and she was diagnosed with HCV-related m...

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Published inIranian journal of kidney diseases Vol. 12; no. 6; p. 382
Main Authors Elmowafy, Ahmed Yahia, El Maghrabi, Hanzada Mohamed, Zahab, Mohamed Ahmed, Elwasif, Salwa Mahmoud, Bakr, Mohamed Adel
Format Journal Article
LanguageEnglish
Published Iran Iranian Society of Nephrology 01.11.2018
Subjects
Antiviral drugs
Hepatitis
Hepatitis C
Interferon
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Summary:Direct antivirals showed dramatic response in hepatitis C virus (HCV) eradication, but their effect on extrahepatic manifestations is still unclear. A 49-year-old woman was referred to us suffering from lower limb edema and frothy urine. Renal biopsy was done and she was diagnosed with HCV-related membranoproliferative glomerulonephritis with cryoglobulinemia. Treatment with interferon plus ribavirin, steroid, and cyclophosphamide was tried but failed. After introduction of a sofosbuvir-based regimen to the treatment, sustained virologic response was achieved and nephrotic syndrome remission was induced successfully. We could conclude that HCV-related membranoproliferative glomerulonephritis with cryoglobulinemia could be treated successfully with immunosuppressive drugs plus sofosbuvir and dacalatasvir.
ISSN:1735-8582
1735-8604