Prevention of diabetes in non-obese diabetic (NOD) mice by short-term and high-dose IGF-I treatment

This report describes the results of IGF-I treatment in a NOD mouse colony with a high incidence of overt diabetes. The animals were treated with IGF-I 17.9 nmol/day at 28-41 days of age and 35.9 nmol/day at 42-69 days of age and observed up to 280 days of age. Three of 12 (25%) IGF-I-treated animal...

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Published inJournal of pediatric endocrinology & metabolism : JPEM Vol. 11; no. 2; pp. 267 - 272
Main Authors Kaino, Y, Hirai, H, Ito, T, Kida, K
Format Journal Article
LanguageEnglish
Published Germany 01.03.1998
Subjects
Animals
Diabetes Mellitus, Type 1 - prevention & control
Female
Insulin - blood
Insulin-Like Growth Factor I - administration & dosage
Insulin-Like Growth Factor I - therapeutic use
Male
Mice
Mice, Inbred NOD
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Summary:This report describes the results of IGF-I treatment in a NOD mouse colony with a high incidence of overt diabetes. The animals were treated with IGF-I 17.9 nmol/day at 28-41 days of age and 35.9 nmol/day at 42-69 days of age and observed up to 280 days of age. Three of 12 (25%) IGF-I-treated animals developed diabetes compared with 8 of 11 (73%) controls (P < 0.05). The severity of insulitis at the conclusion of the follow-up was less pronounced in non-diabetic treated animals than in non-diabetic controls. These data support previous findings that IGF-I treatment protects the pancreatic beta-cells from destruction by diabetic autoimmunity in NOD mice.
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ISSN:0334-018X
DOI:10.1515/JPEM.1998.11.2.267