Colony-forming activity of pluripotent stem cells in tolerant mice following antigen exposure

The effect of sheep red blood cells (SRBC) and human red blood cells (HRBC) on the number of CFU-S in the bone marrow and spleen of (CBA X C57BL/6)F1 mice tolerant to SRBC was examined. The number of bone marrow and spleen CFU-S in SRBC tolerant mice was increased after injection of HRBC. After chal...

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Bibliographic Details
Published inFolia biologica Vol. 33; no. 3; pp. 207 - 210
Main Authors Kozlov, V A, Tsyrlova, I G, Gaidul, K V
Format Journal Article
LanguageEnglish
Published Czech Republic 1987
Subjects
Animals
Antigens - immunology
Bone Marrow - immunology
Bone Marrow Cells
Colony-Forming Units Assay
Erythrocytes - immunology
Hematopoietic Stem Cells - immunology
Immune Tolerance
Male
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Sheep - immunology
Spleen - cytology
Spleen - immunology
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Summary:The effect of sheep red blood cells (SRBC) and human red blood cells (HRBC) on the number of CFU-S in the bone marrow and spleen of (CBA X C57BL/6)F1 mice tolerant to SRBC was examined. The number of bone marrow and spleen CFU-S in SRBC tolerant mice was increased after injection of HRBC. After challenge with SRBC, CFU-S number was elevated in the spleen but not in the bone marrow. Thus, the mechanism of CFU-S activation in response to antigen exposure is different in the bone marrow and spleen.
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ISSN:0015-5500