HLA antigens in diabetics with calcified shoulder periarthritis (CSP)

The distribution frequencies of HLA-A and B antigens was determined in 94 maturity onset diabetics (40 with CSP and 54 without CSP), as well as in 400 unrelated age- and sex-matched Greek controls. The standard NIH technique was used for tissue typing. There was an increased prevalence of the antige...

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Bibliographic Details
Published inClinical and experimental rheumatology Vol. 4; no. 4; p. 351
Main Authors Zervas, J, Mavrikakis, M, Kehayoglou, K, Constantopoulos, C, Toubis, M
Format Journal Article
LanguageEnglish
Published Italy 01.10.1986
Subjects
Calcinosis - complications
Calcinosis - genetics
Calcinosis - immunology
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - genetics
Diabetes Mellitus, Type 1 - immunology
Gene Frequency
HLA Antigens - analysis
HLA Antigens - genetics
Humans
Periarthritis - complications
Periarthritis - immunology
Shoulder
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Summary:The distribution frequencies of HLA-A and B antigens was determined in 94 maturity onset diabetics (40 with CSP and 54 without CSP), as well as in 400 unrelated age- and sex-matched Greek controls. The standard NIH technique was used for tissue typing. There was an increased prevalence of the antigen B27 only in diabetics with CSP (35%) when compared either to the controls (6.8%) or to diabetics without CSP (9.2%). The calculated p-corrected values were Pc = 0.00027 and Pc greater than 0.005 respectively. These findings indicate that the MHC in man may control the genetic susceptibility of a subgroup of insulin-independent diabetics to develop CSP.
ISSN:0392-856X