Labelling of breast carcinoma, thyroid carcinoma and melanoma with manno- and galacto-specific lectins from marine invertebrates

Three marine invertebrate FITC-labelled lectins, CNL, GCL, and GSL, isolated respectively, from the sponges Chondrilla nucula, Geodia cydonium, and the hexacoral Gerardia savaglia, were used as potential diagnostic tools for different breast tumors. The lectins vary in their carbohydrate binding pro...

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Published inEuropean journal of histochemistry Vol. 40; no. 3; pp. 211 - 218
Main Authors Opric, M M, Poznanovic, S, Kljajic, Z, Sladic, D, Pupic, G, Perunovic, B, Gasic, M J
Format Journal Article
LanguageEnglish
Published Italy 1996
Subjects
Animals
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Fluorescein-5-isothiocyanate - metabolism
Galactose - metabolism
Galectins
Hemagglutinins - metabolism
Humans
Lectins - metabolism
Lymphatic Metastasis
Mannose - metabolism
Mannose-Binding Lectins
Melanoma - metabolism
Melanoma - pathology
Porifera
Skin Neoplasms - chemistry
Skin Neoplasms - secondary
Substrate Specificity
Thyroid Neoplasms - metabolism
Thyroid Neoplasms - pathology
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Summary:Three marine invertebrate FITC-labelled lectins, CNL, GCL, and GSL, isolated respectively, from the sponges Chondrilla nucula, Geodia cydonium, and the hexacoral Gerardia savaglia, were used as potential diagnostic tools for different breast tumors. The lectins vary in their carbohydrate binding properties: GSL is D-mannose specific, GCL and CNL D-galactose specific. GSL labels most investigated types of malignant tissues distinctively, while the results with CNL and GCL are less consistent. The well known D-mannose specific lectin, concanavalin A, also binds to tumor tissues, but with much lower intensity than GSL.
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ISSN:1121-760X