Effect of tobramycin on serum pseudocholinesterase levels

Tobramycin given in a single dose of 1 mg.Kg-1 intramuscularly, in healthy male volunteers, did not produce any significant change in serum pseudocholinesterase levels. The above antibiotic given in a single dose of 2 mg.Kg-1 intramuscularly produced a statistically significant increase (p less than...

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Bibliographic Details
Published inMethods and findings in experimental and clinical pharmacology Vol. 4; no. 2; p. 121
Main Authors Paradelis, A G, Balamoutsos, N G, Anastassiadou, G, Veggou, H
Format Journal Article
LanguageEnglish
Published Spain 1982
Subjects
Adult
Anti-Bacterial Agents - pharmacology
Butyrylcholinesterase - blood
Cholinesterases - blood
Humans
Male
Time Factors
Tobramycin - pharmacology
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Summary:Tobramycin given in a single dose of 1 mg.Kg-1 intramuscularly, in healthy male volunteers, did not produce any significant change in serum pseudocholinesterase levels. The above antibiotic given in a single dose of 2 mg.Kg-1 intramuscularly produced a statistically significant increase (p less than 0.05) of serum pseudocholinesterase levels 2 and 4 hours after its administration. However, this increase is very small to have any clinical significance. For the anaesthesiologist, a decrease, rather than an increase, of the serum pseudocholinesterase level should be of clinical significance.
ISSN:0379-0355