Correlations between gross and microscopic lesions in carcinogenic studies in mice

Microscopic diagnoses of a number of spontaneous and induced neoplasms in mice were correlated with the gross findings of the ED01 and a number of other carcinogenic studies conducted at NCTR to determine the value of detailed histopathologic examinations in bioassay testing. The results indicated t...

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Bibliographic Details
Published inJournal of environmental pathology and toxicology Vol. 3; no. 3 Spec No; p. 139
Main Authors Frith, C H, Boothe, A D, Greenman, D L, Farmer, J H
Format Journal Article
LanguageEnglish
Published United States 1980
Subjects
Adrenal Cortex Neoplasms - pathology
Animals
Carcinogens - toxicity
Harderian Gland - pathology
Liver Neoplasms, Experimental - pathology
Lung Neoplasms - pathology
Lymphoma - pathology
Lymphoma, Large B-Cell, Diffuse - pathology
Mammary Neoplasms, Experimental - pathology
Mice
Neoplasms, Experimental - chemically induced
Neoplasms, Experimental - epidemiology
Neoplasms, Experimental - pathology
Pituitary Neoplasms - pathology
Urinary Bladder Neoplasms - pathology
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Summary:Microscopic diagnoses of a number of spontaneous and induced neoplasms in mice were correlated with the gross findings of the ED01 and a number of other carcinogenic studies conducted at NCTR to determine the value of detailed histopathologic examinations in bioassay testing. The results indicated that for organs such as thymus, lung, adrenal, Harderian gland and urinary bladder 50% or more of the neoplastic lesions would be missed if at least one histological section were not examined from each organ. For organs such as the liver and mammary gland, a single tissue section did not greatly improve the ability to detect neoplastic lesions beyond that afforded by a thorough necropsy examination.
ISSN:0146-4779