Intermittent claudication: a controlled study in parallel time of the short-term and long-term effects of cinnarizine

In a group of 45 patients with mild to moderately severe claudication studied over the same 4-month period, cinnarizine administration (75 mg 3-times daily) was associated with a greater than 20% improvement in walking distance in 65% of the patients, who derived significantly more benefit than the...

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Bibliographic Details
Published inPharmatherapeutica Vol. 2; no. 6; p. 401
Main Authors Barber, J H, Reuter, C A, Jageneau, A H, Loots, W
Format Journal Article
LanguageEnglish
Published England 1980
Subjects
Aged
Blood Pressure
Cinnarizine - adverse effects
Cinnarizine - therapeutic use
Double-Blind Method
Drug Evaluation
Female
Humans
Intermittent Claudication - drug therapy
Male
Middle Aged
Patient Compliance
Physical Exertion
Piperazines - therapeutic use
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Summary:In a group of 45 patients with mild to moderately severe claudication studied over the same 4-month period, cinnarizine administration (75 mg 3-times daily) was associated with a greater than 20% improvement in walking distance in 65% of the patients, who derived significantly more benefit than the 30% of placebo responders. The mean improvement in walking distance was 11% for the placebo group compared to 142% for cinnarizine-treated patients. An open 12-month follow-up showed that improvements in walking distance with cinnarizine were maintained in all 12 patients, whereas in the 10 control patients only 10% reported improvement. Objectively, significant plethysmographic improvements were detected only for the cinnarizine-treated patients and shown by an increase in arterial flow-pressure dynamics of the lower limbs.
ISSN:0308-051X