Histologic changes in dog lymph nodes after endolymphatic application of bleomycin oil suspension

Bleomycin oil suspension (Oil-Bleo) was injected endolymphatically in a dog experiment. The drug remained in lymph nodes over many weeks in detectable concentrations. The histologic changes in these lymph nodes were examined and compared with 3 controls (aqueous Bleomycin, Lipiodol, and no treatment...

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Bibliographic Details
Published inLymphology Vol. 22; no. 2; pp. 100 - 102
Main Authors Hirnle, P, Geppert, M
Format Journal Article
LanguageEnglish
Published United States 01.06.1989
Subjects
Animals
Bleomycin - administration & dosage
Bleomycin - pharmacology
Dogs
Injections, Intralymphatic
Lymph Nodes - drug effects
Oils
Suspensions
Time Factors
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Summary:Bleomycin oil suspension (Oil-Bleo) was injected endolymphatically in a dog experiment. The drug remained in lymph nodes over many weeks in detectable concentrations. The histologic changes in these lymph nodes were examined and compared with 3 controls (aqueous Bleomycin, Lipiodol, and no treatment). Granulomatous reaction, microabscesses, and small necrotic foci were observed. After a month, fibrosis was detectable in all lymph nodes. The damage to microscopic lymph node structures after Oil-Bleo was moderate. These findings suggest that Oil-Bleo may be useful in local treatment of lymph node metastases.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0024-7766