Inhibition of rat serum polyphenoloxidase activity by silver ions abolished by administration of copper ions

The administration of silver nitrate (6.47 mg, i.e. 60 mumol Ag+/rat/day) in food was followed in only two days by a pronounced decrease in polyphenoloxidase activity (ceruloplasmin) in rat serum. The administration of copper in the form of copper sulphate (12.7 mg, i.e. 200 mumol Cu2+/rat/day) rais...

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Bibliographic Details
Published inFolia biologica Vol. 26; no. 1; p. 47
Main Authors Pribyl, T, Schreiber, V, Jahodová, J
Format Journal Article
LanguageEnglish
Published Czech Republic 1980
Subjects
Animals
Ceruloplasmin - antagonists & inhibitors
Ceruloplasmin - blood
Copper - pharmacology
Diet
Drug Interactions
Male
Oxidoreductases - blood
Rats
Silver - pharmacology
Time Factors
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Summary:The administration of silver nitrate (6.47 mg, i.e. 60 mumol Ag+/rat/day) in food was followed in only two days by a pronounced decrease in polyphenoloxidase activity (ceruloplasmin) in rat serum. The administration of copper in the form of copper sulphate (12.7 mg, i.e. 200 mumol Cu2+/rat/day) raised polyphenoloxidase activity (the ceruloplasmin level), the increase being particularly marked on the first four days. On combining the two factors, the effect of Cu+ predominated throughout the duration of the experiment (32 days).
ISSN:0015-5500