Autoantibodies in Greek juvenile chronic arthritis patients

The aim of this study was to investigate sera of Greek patients with juvenile chronic arthritis (JCA) for the presence of autoantibodies and correlate these antibodies with the clinical picture and disease activity. Sera from 69 JCA patients and sera from 66 healthy children matched for sex and age,...

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Published inClinical and experimental rheumatology Vol. 9; no. 6; p. 647
Main Authors Siamopoulou-Mavridou, A, Mavridis, A K, Terzoglou, C, Filopoulou, S, Athanasiadou, S, Tzioufas, A G
Format Journal Article
LanguageEnglish
Published Italy 01.11.1991
Subjects
Adolescent
Antibodies, Antinuclear - analysis
Antigens, Nuclear
Arthritis, Juvenile - blood
Arthritis, Juvenile - epidemiology
Arthritis, Juvenile - immunology
Autoantibodies - analysis
Cardiolipins - analysis
Child
Child, Preschool
DNA - immunology
Enzyme-Linked Immunosorbent Assay
Female
Fluorescent Antibody Technique
Greece - epidemiology
Humans
Immunoglobulin G - analysis
Immunoglobulin M - analysis
Infant
Male
Nuclear Proteins - analysis
Rheumatoid Factor - analysis
Greece
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Summary:The aim of this study was to investigate sera of Greek patients with juvenile chronic arthritis (JCA) for the presence of autoantibodies and correlate these antibodies with the clinical picture and disease activity. Sera from 69 JCA patients and sera from 66 healthy children matched for sex and age, were tested for antinuclear antibodies (ANAs), antibodies to extractable cellular antigens (ENAs), rheumatoid factor (RF), immunoglobulins (IgG, IgM), antibodies to double stranded (ds) DNA and anticardiolipin (CL). Our results indicate that: (a) autoantibodies to dsDNA are a not uncommon finding in JCA sera; (b) these autoantibodies have a low affinity for the antigen since they are found in low titers only by ELISA, while the Farr assay and Crithidia lucilliae immunofluorescence assay (IF) are negative; and (c) active JCA patients express many autoantibodies.
ISSN:0392-856X
1593-098X