Polymorphic changes of mannitol during freeze-drying: effect of surface-active agents

The effect of polysorbate 80 on the crystalline properties of mannitol during freeze-drying was studied. Crystallinity and polymorphism play an important role in, e.g., the solubility and stability of freeze-dried products. Polysorbate 80 had an effect on both the polymorphism and the crystallinity...

Full description

Saved in:
Bibliographic Details
Published inPDA journal of pharmaceutical science and technology Vol. 51; no. 2; p. 96
Main Authors Haikala, R, Eerola, R, Tanninen, V P, Yliruusi, J
Format Journal Article
LanguageEnglish
Published United States 01.03.1997
Subjects
Crystallization
Drug Stability
Freeze Drying
Mannitol - chemistry
Microscopy, Electron, Scanning
Polysorbates - pharmacology
Solutions
Surface Properties
Surface-Active Agents - pharmacology
X-Ray Diffraction
Online AccessGet more information

Cover

More Information
Summary:The effect of polysorbate 80 on the crystalline properties of mannitol during freeze-drying was studied. Crystallinity and polymorphism play an important role in, e.g., the solubility and stability of freeze-dried products. Polysorbate 80 had an effect on both the polymorphism and the crystallinity of freeze-dried mannitol.
ISSN:1079-7440
1948-2124