Synthesis and 5-HT receptors binding studies of some 3-substituted-2-(4-methyl-1-piperazinyl)-4-phenylquinolines

The syntheses of some 3-substituted-2-(4-methyl-1-piperazinyl)-4-phenylquinolines are reported. The title compounds were tested for their potential activities on 5-HT receptor subtypes and 5-HT uptake site; compounds 4b-d showed micromolar affinity for 5-HT3 and 5-HT uptake site.

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Bibliographic Details
Published inFarmaco (Società chimica italiana : 1989) Vol. 46; no. 12; p. 1435
Main Authors Anzini, M, Cappelli, A, Vomero, S, Campiani, G, Cagnotto, A, Skorupska, M
Format Journal Article
LanguageEnglish
Published France 01.12.1991
Subjects
Animals
Binding, Competitive - drug effects
In Vitro Techniques
Ligands
Male
Paroxetine
Piperazines - chemical synthesis
Piperazines - pharmacology
Piperidines - metabolism
Quinolones - chemical synthesis
Quinolones - pharmacology
Quipazine - analogs & derivatives
Quipazine - chemical synthesis
Quipazine - pharmacology
Rats
Rats, Inbred Strains
Serotonin - metabolism
Serotonin Antagonists
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Summary:The syntheses of some 3-substituted-2-(4-methyl-1-piperazinyl)-4-phenylquinolines are reported. The title compounds were tested for their potential activities on 5-HT receptor subtypes and 5-HT uptake site; compounds 4b-d showed micromolar affinity for 5-HT3 and 5-HT uptake site.
ISSN:0014-827X