Some pharmacological properties of prolonged administration of Ukrain in rodents

Some pharmacological properties of Ukrain administered intraperitoneally (i.p.) once daily for three months in mice and rats of both sexes were studied. A three month treatment with Ukrain significantly depressed the spontaneous locomotor activity and did not affect the motor coordination of mice an...

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Published inDrugs under experimental and clinical research Vol. 18 Suppl; p. 93
Main Authors Kleinrok, Z, Jagiełł-Wójtowicz, E, Nowicky, J W, Chodkowska, A, Feldo, M, Matuszek, B
Format Journal Article
LanguageEnglish
Published Switzerland 1992
Subjects
Alkaloids - pharmacology
Animals
Berberine Alkaloids
Brain Chemistry - drug effects
Dopamine - metabolism
Female
Hydroxyindoleacetic Acid - metabolism
Male
Mice
Motor Activity - drug effects
Norepinephrine - metabolism
Organ Size - drug effects
Phenanthridines
Postural Balance - drug effects
Rats
Rats, Wistar
Serotonin - metabolism
Species Specificity
Weight Gain - drug effects
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Summary:Some pharmacological properties of Ukrain administered intraperitoneally (i.p.) once daily for three months in mice and rats of both sexes were studied. A three month treatment with Ukrain significantly depressed the spontaneous locomotor activity and did not affect the motor coordination of mice and rats of both sexes. Ukrain did not affect the body weight gain as well as the mass of internal organs; the exception was an increase in the mass of the spleen in rats. Biochemical studies indicated that a three month treatment with Ukrain depressed the whole brain dopamine (DA) concentrations and did not affect the noradrenaline (NA) concentrations. Long-term administration of Ukrain showed no characteristic changes in the concentrations of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in the whole brain. The observed changes after three months' treatment with Ukrain are similar in mice and rats of both sexes.
ISSN:0378-6501