A model system for studying initial events in atherosclerosis

A model system has been developed which employs the central artery of the rabbit ear, and allows for the study of 1) ultra-structural changes in the arterial endothelium and 2) formation and release of prostacyclin and thromboxane from the arteries in situ. Use of the model should be helpful in eval...

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Bibliographic Details
Published inArtery Vol. 8; no. 1; p. 80
Main Authors Silver, M J, Sedar, A W, Nissenbaum, M, Ingerman, C, Smith, J B
Format Journal Article
LanguageEnglish
Published United States 1980
Subjects
Animals
Arachidonic Acids - pharmacology
Arteriosclerosis - physiopathology
Disease Models, Animal
Ear - blood supply
Endothelium - ultrastructure
Epoprostenol - biosynthesis
Male
Rabbits
Thromboxane B2 - biosynthesis
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Summary:A model system has been developed which employs the central artery of the rabbit ear, and allows for the study of 1) ultra-structural changes in the arterial endothelium and 2) formation and release of prostacyclin and thromboxane from the arteries in situ. Use of the model should be helpful in evaluating the initial events in atherosclerosis. Both prostacyclin and thromboxane (detected by radioimmunoassay) were formed by arteries in situ in response to infusion of sodium arachidonate.
ISSN:0098-6127