Hepar lobatum associated with chemotherapy and metastatic breast cancer

Hepar lobatum is now a rarity in developed countries. In this article, we describe three cases with typical liver morphology associated with carcinoma of the breast metastatic to the liver, treated with combination chemotherapy. The pathogenesis of hepar lobatum in our cases is multifactorial with t...

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Bibliographic Details
Published inArchives of pathology & laboratory medicine (1976) Vol. 111; no. 1; p. 58
Main Authors Qizilbash, A, Kontozoglou, T, Sianos, J, Scully, K
Format Journal Article
LanguageEnglish
Published United States 01.01.1987
Subjects
Adenocarcinoma - drug therapy
Adenocarcinoma - secondary
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Breast Neoplasms - drug therapy
Carcinoma, Intraductal, Noninfiltrating - drug therapy
Carcinoma, Intraductal, Noninfiltrating - secondary
Female
Humans
Liver - drug effects
Liver - pathology
Liver Neoplasms - drug therapy
Liver Neoplasms - secondary
Middle Aged
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Summary:Hepar lobatum is now a rarity in developed countries. In this article, we describe three cases with typical liver morphology associated with carcinoma of the breast metastatic to the liver, treated with combination chemotherapy. The pathogenesis of hepar lobatum in our cases is multifactorial with tumor-related desmoplasia and effects of chemotherapy, with resultant tumor necrosis and fibrosis playing a major role.
ISSN:0003-9985
1543-2165