Antiviral effects on mouse leukemia virus replication by oligodeoxynucleotides in vitro and in vivo

Oligodeoxynucleotides (Oligomers) including modified and unmodified, homo- and heterooligomers were tested for their ability to inhibit mouse SRS leukemia virus (SRSV)-induced proliferation of cells, colony formation, syncytium formation and reverse transcriptase (RT) activity in vitro. Phosphorothi...

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Bibliographic Details
Published inChinese medical journal Vol. 107; no. 2; p. 146
Main Authors Shan, Y F, Gao, H Y, Ji, H, Qiu, M S, Wang, D B
Format Journal Article
LanguageEnglish
Published China 01.02.1994
Subjects
Animals
Antiviral Agents - pharmacology
Base Sequence
Leukemia Virus, Murine - drug effects
Leukemia Virus, Murine - physiology
Lymphoma - drug therapy
Mice
Molecular Sequence Data
Neoplasm Transplantation
Oligonucleotides, Antisense - pharmacology
Polymerase Chain Reaction
Retroviridae Infections
Tumor Cells, Cultured - drug effects
Tumor Virus Infections
Virus Replication - drug effects
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Summary:Oligodeoxynucleotides (Oligomers) including modified and unmodified, homo- and heterooligomers were tested for their ability to inhibit mouse SRS leukemia virus (SRSV)-induced proliferation of cells, colony formation, syncytium formation and reverse transcriptase (RT) activity in vitro. Phosphorothioate analogs complementary to Mo-MuLV sequences, as well as noncomplementary homooligomers, were found to be active. Unmodified homooligomer (dC14) also showed inhibition of growth of ascitic lymphoma carrying SRS virus. Our study suggests that different classes of oligonucleotides may inhibit SRSV replication with different mechanisms.
ISSN:0366-6999
2542-5641