The bronchodilator effect of fenoterol (Berotec)

The efficacy of the selective beta 2 sympathomimetic fenoterol (Berotec) in aerosol and tablet forms was studied in 15 subjects with reversible airways obstruction. The maximal bronchodilator effect of fenoterol by aerosol (0.4mg) was found to equal that of isoprenaline, and to be maintained at that...

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Bibliographic Details
Published inNew Zealand medical journal Vol. 81; no. 535; p. 249
Main Author Powles, A C
Format Journal Article
LanguageEnglish
Published New Zealand 12.03.1975
Subjects
Adolescent
Adult
Aerosols
Airway Obstruction - drug therapy
Airway Obstruction - physiopathology
Asthma - drug therapy
Asthma - physiopathology
Bronchodilator Agents - administration & dosage
Bronchodilator Agents - adverse effects
Bronchodilator Agents - therapeutic use
Ethanolamines - administration & dosage
Female
Fenoterol - administration & dosage
Fenoterol - therapeutic use
Humans
Isoproterenol - therapeutic use
Male
Metaproterenol - administration & dosage
Metaproterenol - analogs & derivatives
Metaproterenol - therapeutic use
Middle Aged
Spirometry
Tablets
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Summary:The efficacy of the selective beta 2 sympathomimetic fenoterol (Berotec) in aerosol and tablet forms was studied in 15 subjects with reversible airways obstruction. The maximal bronchodilator effect of fenoterol by aerosol (0.4mg) was found to equal that of isoprenaline, and to be maintained at that level over the three hour period studied. When given orally, neither one tablet (2.5 mg) nor two tablets (5 mg) of fenoterol increased the FEV1 to the same extent as isoprenaline, and the larger oral dose (5 mg) produced troublesome side effects in several subjects. It is concluded that fenoterol by aerosol is an effective bronchodilator with a duration of action of at least three hours, without significant side effects.
ISSN:0028-8446