The clinical value of urinary polyamine analyses in cancer patients

The polyamines, putrescine (P) and spermidine (S), have been measured in 185 cancer patients. Patients in remission exhibited significantly different levels from those with active disease. In a dynamic patient study, followed over a period of 5-6 months, the urinary polyamine levels correlated close...

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Bibliographic Details
Published inOncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine Vol. 1; no. 4-5; p. 215
Main Authors Milano, G, Viguier, E, LaLanne, C M, Pastorini, P, Cassuto, J P, Schneider, M, Cambon, P, Boublil, J L
Format Journal Article
LanguageEnglish
Published Netherlands 1980
Subjects
Adolescent
Adult
Aged
Female
Humans
Male
Middle Aged
Neoplasms - drug therapy
Neoplasms - urine
Polyamines - urine
Putrescine - urine
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Summary:The polyamines, putrescine (P) and spermidine (S), have been measured in 185 cancer patients. Patients in remission exhibited significantly different levels from those with active disease. In a dynamic patient study, followed over a period of 5-6 months, the urinary polyamine levels correlated closely with the clinical status. Furthermore, polyamines have been measured 24 h before beginning chemotherapy (P1, S1) and 48 h after its onset (P2, S2). The value of the ratio, (S2/P2)/(S1/P1), was found to correlate with the type of response to chemotherapy.
ISSN:0167-1618