Effects of ergot alkaloids on stress-induced analgesia

Repeated, thirty minute anticipation of unavoidable painful stimulation causes endorphin-induced analgesia in rats. This type of stress-induced analgesia (SIA) develops rapidly during the first minutes of the exposure to anticipation stress. SIA can be demonstrated during the whole period of anticip...

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Bibliographic Details
Published inPhysiologia Bohemoslovaca Vol. 35; no. 3; p. 269
Main Authors Jakoubek, B, Sumová, A, Kosar, E, Dĕdicová, A
Format Journal Article
LanguageEnglish
Published Czech Republic 1986
Subjects
Animals
Dihydroergotoxine
Endorphins - physiology
Ergot Alkaloids - pharmacology
Lisuride - analogs & derivatives
Male
Pain - physiopathology
Rats
Receptors, Opioid - drug effects
Stress, Physiological - physiopathology
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Summary:Repeated, thirty minute anticipation of unavoidable painful stimulation causes endorphin-induced analgesia in rats. This type of stress-induced analgesia (SIA) develops rapidly during the first minutes of the exposure to anticipation stress. SIA can be demonstrated during the whole period of anticipation stress. Ergot drugs (DH--ergotoxine, lisuride, trans-9,10 dihydrolisuride) administered 30 min before the onset of anticipation stress, blocked completely this form of SIA. On the other hand, no effect of ergot alkaloids in the tail-flick latency, as measured under resting conditions, was observed. Possible interactions of ergot alkaloids with opiate receptors as an important mechanism by which ergot drugs affect SIA are discussed.
ISSN:0369-9463