Morphological and functional characterization of cell cultures from adult human adenohypophyses

Parallel primary cultures have been prepared from dispersed cells of adult human pituitary anterior lobes and can be used as a model system for cell-biological studies. The cultured cells were able to secrete all the known hormones of the adenohypophysis. Bromocriptine administration markedly reduce...

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Bibliographic Details
Published inActa histochemica. Supplementband Vol. 42; p. 231
Main Authors Bácsy, E, Gyévai, A, Szabó, M, Nagy, I, Sótonyi, P
Format Journal Article
LanguageEnglish
Published Germany 1992
Subjects
Antibodies, Monoclonal
Bromocriptine - pharmacology
Cells, Cultured
Humans
Immunoassay
Immunohistochemistry
Pituitary Gland, Anterior - drug effects
Pituitary Gland, Anterior - physiology
Pituitary Gland, Anterior - ultrastructure
Pituitary Hormones - analysis
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Summary:Parallel primary cultures have been prepared from dispersed cells of adult human pituitary anterior lobes and can be used as a model system for cell-biological studies. The cultured cells were able to secrete all the known hormones of the adenohypophysis. Bromocriptine administration markedly reduced prolactin release into the medium while slightly enhanced growth hormone release. The adequate response of somatotrophs to GRF and SRIF could not be demonstrated.
ISSN:0567-7556