Studies of the intestinal metabolism of oral gold

In order to understand some of the unique toxic/therapeutic properties of the orally administered gold containing compound auranofin, the intestinal metabolism of gold was studied in 4 normal subjects. A triple lumen intestinal perfusion apparatus was used to measure intestinal flux using a non-abso...

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Bibliographic Details
Published inJournal of rheumatology Vol. 7; no. 5; p. 633
Main Authors Weisman, M H, Hardison, W G, Walz, D T
Format Journal Article
LanguageEnglish
Published Canada 01.09.1980
Subjects
Administration, Oral
Adult
Auranofin
Aurothioglucose - administration & dosage
Aurothioglucose - analogs & derivatives
Aurothioglucose - therapeutic use
Gold - analogs & derivatives
Humans
Intestinal Absorption
Intestinal Mucosa - metabolism
Intestine, Small - metabolism
Male
Middle Aged
Perfusion
Phosphines - administration & dosage
Phosphines - therapeutic use
Time Factors
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Summary:In order to understand some of the unique toxic/therapeutic properties of the orally administered gold containing compound auranofin, the intestinal metabolism of gold was studied in 4 normal subjects. A triple lumen intestinal perfusion apparatus was used to measure intestinal flux using a non-absorbable radiolabelled marker dilution technique. Over a short (50 cm) segment of proximal small bowel, substantial disappearance of gold was observed; the findings, however, were most consistent with a loose, reversible adsorption onto the enteric cell surface rather than true trans-mucosal absorption. There was no evidence for an entero-hepatic recirculation of gold in these subjects or in 4 additional patients with rheumatoid arthritis studied in a similar manner.
ISSN:0315-162X