Amplification of the epidermal growth factor receptor gene in human gliomas

Biopsy specimens of 19 human gliomas (10 glioblastomas, 2 anaplastic astrocytomas, 4 astrocytomas, one mixed glioma, one oligodendroglioma and one ependymoma) were examined for amplification of tumour-related genes located on chromosome 7: the proto-oncogene c-erb-B1 (encoding the epidermal growth f...

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Bibliographic Details
Published inAnticancer research Vol. 11; no. 6; p. 2095
Main Authors Torp, S H, Helseth, E, Ryan, L, Stølan, S, Dalen, A, Unsgaard, G
Format Journal Article
LanguageEnglish
Published Greece 01.11.1991
Subjects
Adult
Aged
Astrocytoma - genetics
Chromosomes, Human, Pair 7
Ependymoma - genetics
Female
Gene Amplification
Glioma - genetics
Humans
Male
Middle Aged
Oligodendroglioma - genetics
Receptor, Epidermal Growth Factor - genetics
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Summary:Biopsy specimens of 19 human gliomas (10 glioblastomas, 2 anaplastic astrocytomas, 4 astrocytomas, one mixed glioma, one oligodendroglioma and one ependymoma) were examined for amplification of tumour-related genes located on chromosome 7: the proto-oncogene c-erb-B1 (encoding the epidermal growth factor receptor (EGFR], the proto-oncogene c-met, the platelet-derived growth factor A-chain gene, and the plasminogen activator inhibitor type-1 gene. Gene amplification was observed in 6 glioblastomas, and the EGFR gene was the only chromosome-7-gene examined that was amplified. The selective EGFR gene amplification in human glioblastomas suggests its potential role in the progression of some of these tumours.
ISSN:0250-7005