Inhibition of the hepatocarcinogenic activity of diethylnitrosamine (DENA) by ethanol in rats

Male Sprague-Dawley rats received 0.1 mg/kg of diethyl-nitrosamine orally five times a week for life with or without additional subsequent administration of 5 ml/rat/day of a 25% aqueous solution of ethanol. The additional treatment with ethanol significantly reduced the induction of liver cancer, b...

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Bibliographic Details
Published inHepato-gastroenterology Vol. 28; no. 5; p. 242
Main Authors Habs, M, Schmähl, D
Format Journal Article
LanguageEnglish
Published Greece 01.10.1981
Subjects
Animals
Diethylnitrosamine - antagonists & inhibitors
Esophageal Neoplasms - chemically induced
Ethanol - pharmacology
Liver Neoplasms, Experimental - chemically induced
Male
Neoplasms, Experimental - chemically induced
Nitrosamines - antagonists & inhibitors
Rats
Rats, Inbred Strains
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Summary:Male Sprague-Dawley rats received 0.1 mg/kg of diethyl-nitrosamine orally five times a week for life with or without additional subsequent administration of 5 ml/rat/day of a 25% aqueous solution of ethanol. The additional treatment with ethanol significantly reduced the induction of liver cancer, but not of esophageal tumors. These findings do not support speculations based on epidemiologic studies as to a cancer-causing effect of alcohol.
ISSN:0172-6390