Bradykinin inhibits rat myometrial adenylate cyclase activity via a high-affinity receptor

Bradykinin (BK) which contracts the rat uterus inhibited at subnanomolar concentrations rat myometrial adenylate cyclase stimulated by NaF or guanyl nucleotides by about 40%. The effect was maximal at about 10 to 100 pM. At a higher concentration (100 nM), bradykinin was ineffective. Together with r...

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Bibliographic Details
Published inBiomedica biochimica acta Vol. 49; no. 11; p. 1231
Main Authors Liebmann, C, Reissmann, S
Format Journal Article
LanguageEnglish
Published Germany 1990
Subjects
Adenylyl Cyclases - metabolism
Animals
Bradykinin - pharmacology
Cell Membrane - drug effects
Cell Membrane - enzymology
Female
Myometrium - drug effects
Myometrium - enzymology
Rats
Receptors, Bradykinin
Receptors, Neurotransmitter - drug effects
Receptors, Neurotransmitter - metabolism
Sodium Fluoride - pharmacology
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Summary:Bradykinin (BK) which contracts the rat uterus inhibited at subnanomolar concentrations rat myometrial adenylate cyclase stimulated by NaF or guanyl nucleotides by about 40%. The effect was maximal at about 10 to 100 pM. At a higher concentration (100 nM), bradykinin was ineffective. Together with recently presented results these data suggest that in rat myometrium the adenylate cyclase may be coupled by a G12/G13-type G-protein to a high-affinity BK receptor.
ISSN:0232-766X