Binding of sucralfate to duodenal ulcer in man

Biopsy specimens of ulcerated and of adjacent non-ulcerated duodenal mucosa were obtained from 17 patients with active duodenal ulcer who had received a single oral dose of 1 g sucralfate. Similar specimens were obtained from 21 patients with a recently healed duodenal ulcer. The specimens were assa...

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Bibliographic Details
Published inScandinavian journal of gastroenterology. Supplement Vol. 83; p. 13
Main Authors Sasaki, H, Hinohara, Y, Tsunoda, Y, Nagashima, R
Format Journal Article
LanguageEnglish
Published England 1983
Subjects
Aluminum - metabolism
Aluminum - therapeutic use
Anti-Ulcer Agents - metabolism
Anti-Ulcer Agents - therapeutic use
Duodenal Ulcer - drug therapy
Duodenal Ulcer - metabolism
Humans
Intestinal Mucosa - metabolism
Sucralfate
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Summary:Biopsy specimens of ulcerated and of adjacent non-ulcerated duodenal mucosa were obtained from 17 patients with active duodenal ulcer who had received a single oral dose of 1 g sucralfate. Similar specimens were obtained from 21 patients with a recently healed duodenal ulcer. The specimens were assayed for aluminum to provide an estimate of the amount of sucralfate bound to the mucosa. Sucralfate was present at significantly higher concentrations in ulcerated mucosa than in non-ulcerated mucosa for 6 hr after dosing. In addition, sucralfate was found to bind to healed duodenal ulcers for 6 hr after dosing. This finding provides a rational basis for the use of sucralfate in the maintenance therapy of duodenal ulcer.
ISSN:0085-5928
1751-1895