Combined radioprotection by preirradiation peroral cystamine and postirradiation glucan administration

The possibilities of combined radioprotection, using preirradiation peroral cystamine and postirradiation intraperitoneal glucan administration in sublethally and lethally whole-body gamma-irradiated mice were investigated. The results demonstrated at least additive radioprotective effects of both a...

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Bibliographic Details
Published inFolia biologica Vol. 37; no. 2; p. 117
Main Authors Pospísil, M, Netíková, J, Pipalová, I, Jarý, J
Format Journal Article
LanguageEnglish
Published Czech Republic 1991
Subjects
Animals
beta-Glucosidase - pharmacology
Bone Marrow - drug effects
Bone Marrow - radiation effects
Cystamine - administration & dosage
Cystamine - pharmacology
Drug Interactions
Femur
Gamma Rays
Glucan 1,3-beta-Glucosidase
Hematopoiesis - drug effects
Hematopoiesis - radiation effects
Hematopoietic Stem Cells - drug effects
Hematopoietic Stem Cells - radiation effects
Male
Mice
Radiation Tolerance
Radiation-Protective Agents - pharmacology
Spleen - drug effects
Spleen - radiation effects
Whole-Body Irradiation
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Summary:The possibilities of combined radioprotection, using preirradiation peroral cystamine and postirradiation intraperitoneal glucan administration in sublethally and lethally whole-body gamma-irradiated mice were investigated. The results demonstrated at least additive radioprotective effects of both agents, manifested in the enhancement of postirradiation haemopoietic recovery and increased survival of irradiated mice. The effects appear to depend on the sequential cell protection mediated by cystamine and enhanced haemopoietic repopulation induced by glucan.
ISSN:0015-5500