Bradykinin action in the rat duodenum: influence of a duodenum contracting bradykinin partial sequence on the cAMP level

A modified bradykinin partial sequence (PP) contracts the isolated rat duodenum, inhibits the adenylate cyclase activity and decreases the cAMP level. These effects are dependent on the presence of free Ca++. The PP acts in contrast to bradykinin itself, which relaxes the rat duodenum and stimulates...

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Bibliographic Details
Published inBiomedica biochimica acta Vol. 47; no. 6; p. 471
Main Authors Liebmann, C, Reissmann, S
Format Journal Article
LanguageEnglish
Published Germany 1988
Subjects
Adenylyl Cyclases - metabolism
Animals
Bradykinin - pharmacology
Calcium - pharmacology
Cell Membrane - enzymology
Cyclic AMP - metabolism
Duodenum - drug effects
Duodenum - metabolism
Egtazic Acid - pharmacology
Female
In Vitro Techniques
Oligopeptides - pharmacology
Rats
Rats, Inbred Strains
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Summary:A modified bradykinin partial sequence (PP) contracts the isolated rat duodenum, inhibits the adenylate cyclase activity and decreases the cAMP level. These effects are dependent on the presence of free Ca++. The PP acts in contrast to bradykinin itself, which relaxes the rat duodenum and stimulates adenylate cyclase. The results further support the involvement of both cAMP and Ca++ in bradykinin action on rat duodenum smooth muscle.
ISSN:0232-766X