Chemical structure and biological activity relationship in bradykinin analogues containing proline-like unusual amino acids

Ten different bradykinin analogues have been synthesized and tested for activity on isolated guinea-pig ileum. The results, in comparison with others in the literature, suggest some conclusions on a chemical structure - biological activity relationship.

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Bibliographic Details
Published inActa biochimica et biophysica Hungarica Vol. 21; no. 4; p. 363
Main Authors Baláspiri, L, Tóth, M V, Lonovics, J, Kovács, K
Format Journal Article
LanguageEnglish
Published Hungary 1986
Subjects
Animals
Bradykinin - analogs & derivatives
Bradykinin - pharmacology
Guinea Pigs
In Vitro Techniques
Muscle Contraction - drug effects
Muscle, Smooth - physiology
Pipecolic Acids
Proline - analogs & derivatives
Structure-Activity Relationship
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Summary:Ten different bradykinin analogues have been synthesized and tested for activity on isolated guinea-pig ileum. The results, in comparison with others in the literature, suggest some conclusions on a chemical structure - biological activity relationship.
ISSN:0237-6261