Local bacillus Calmette-Guérin therapy for bovine vulval papilloma and carcinoma

• Published in: Cancer Immunology, Immunotherapy : CII Vol. 39; no. 1; pp. 49 - 52
• Main Authors: HILL, F. W. G, RUTTEN, V. P. M. G, HOYER, M. H, KLEIN, W. R, KOTEN, J. W, STEERENBERG, P. A, RUITENBERG, E. J, DEN OTTER, W
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.07.1994; Springer-Verlag
• Subjects: Animals; Antineoplastic agents; BCG Vaccine - therapeutic use; Biological and medical sciences; Cattle; Cattle Diseases - therapy; Female; Immunotherapy; Injections, Intralesional; Injections, Subcutaneous; Medical sciences; Original; Papilloma - therapy; Papilloma - veterinary; Pharmacology. Drug treatments; Vulvar Neoplasms - therapy; Vulvar Neoplasms - veterinary; Antineoplastic agent; Carcinoma; Bovine; BCG; Early stage; Vulva; Malignant tumor; Veterinary medicine; Female genital diseases; Local administration; Vertebrata; Immunostimulant agent; Mammalia; Treatment; Animal; Immunotherapy; Vulvar diseases; Papilloma; Advanced stage; Artiodactyla; Benign neoplasm; Ungulata
• ISSN: 0340-7004; 1432-0851
• DOI: 10.1007/BF01517180

Thirty cows from a pedigree Friesian dairy herd with bovine vulva papilloma and carcinoma were treated by intralesional injections of live bacillus Calmette-Guérin (BCG). This treatment induced total regression of all of six carcinomas. Whilst, after treatment, limited regression was also observed in advanced papillomas, BCG has little or no effect on the early stages of papillomas. This is the first study of BCG therapy in this type of cancer.