A three center study on the diagnostic accuracy of 99mTc-MIBI scintimammography

In order to assess specificity and sensitivity of the prone scintimammography (PSM) in a large series with 99m-Tc MIBI, we performed a three-center study; 420 patients were studied; after mammography all the patients were submitted to PSM and biopsy and/or operation. PSM was considered positive if h...

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Bibliographic Details
Published inAnticancer research Vol. 17; no. 3B; p. 1631
Main Authors Scopinaro, F, Schillaci, O, Ussof, W, Nordling, K, Capoferro, R, De Vincentis, G, Danieli, R, Ierardi, M, Picardi, V, Tavolaro, R, Colella, A C
Format Journal Article
LanguageEnglish
Published Greece 01.05.1997
Subjects
Adult
Aged
Biopsy
Breast Diseases - diagnostic imaging
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - pathology
Breast Neoplasms - surgery
False Negative Reactions
False Positive Reactions
Female
Humans
Mammography
Middle Aged
Neoplasm Staging
Predictive Value of Tests
Radionuclide Imaging
Reproducibility of Results
Sensitivity and Specificity
Technetium Tc 99m Sestamibi
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Summary:In order to assess specificity and sensitivity of the prone scintimammography (PSM) in a large series with 99m-Tc MIBI, we performed a three-center study; 420 patients were studied; after mammography all the patients were submitted to PSM and biopsy and/or operation. PSM was considered positive if hot spot within the breast was observed. In palpable masses sensitivity was 0.98 and specificity 0.89, non palpable masses showed a sensitivity of 0.62 and a specificity of 0.91. When the cancers were stratified for T category the sensitivity was 0.28 in T1a 0.26 in the group of T1a carcinomas, 0.56 in T1b 0.95 in T1c and 0.97 T2 tumors. Physical factors such as attenuation. Compton scattering from chest, as well as biological factors have a role in breast tumor imaging. In the tumors smaller than 1 cm biological factors are probably involved too.
ISSN:0250-7005