Anti-mutagenic chalcones: antagonizing the mutagenicity of benzo(a)pyrene on Salmonella typhimurium

Several chalcone derivatives; e.g. Ro 09-0204, Ro 09-0323 and Ro 09-0501 were found to reduce markedly the revertant increase of Salmonella typhimurium TA100 by benzo(a)pyrene during the incubation with S-9 Mix. The antimutagenic activity was 100 - 700 times stronger than that of L-ascorbic acid. Ef...

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Bibliographic Details
Published inBiochemical and biophysical research communications Vol. 112; no. 3; p. 833
Main Authors Torigoe, T, Arisawa, M, Itoh, S, Fujiu, M, Maruyama, H B
Format Journal Article
LanguageEnglish
Published United States 16.05.1983
Subjects
Benzo(a)pyrene
Benzopyrenes - antagonists & inhibitors
Chalcone - analogs & derivatives
Chalcone - pharmacology
Mutagenicity Tests
Mutagens - antagonists & inhibitors
Propiophenones - pharmacology
Salmonella typhimurium - genetics
Structure-Activity Relationship
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Summary:Several chalcone derivatives; e.g. Ro 09-0204, Ro 09-0323 and Ro 09-0501 were found to reduce markedly the revertant increase of Salmonella typhimurium TA100 by benzo(a)pyrene during the incubation with S-9 Mix. The antimutagenic activity was 100 - 700 times stronger than that of L-ascorbic acid. Effect on other mutagens, the structure activity relationship and the possible mechanism of action are briefly discussed.
ISSN:0006-291X
DOI:10.1016/0006-291X(83)91693-5