Solid-phase synthesis of oligoribonucleotides

An efficient method is described for solid-phase synthesis of oligoribonucleotides that involves use of the 9-fluorenylmethoxycarbonyl group (Fmoc) for 5'-protection, 4-methoxytetrahydropyran-4-yl (Mthp) for 2'-protection and a phosphoramidite coupling procedure.

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Bibliographic Details
Published inNucleic acids symposium series (1979) no. 21; pp. 39 - 40
Main Authors Xu, Y Z, Lehmann, C, Slim, G, Christodoulou, C, Tan, Z K, Gait, M J
Format Journal Article
LanguageEnglish
Published England 1989
Subjects
Drug Stability
Glass
Indicators and Reagents
Oligoribonucleotides - chemical synthesis
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Summary:An efficient method is described for solid-phase synthesis of oligoribonucleotides that involves use of the 9-fluorenylmethoxycarbonyl group (Fmoc) for 5'-protection, 4-methoxytetrahydropyran-4-yl (Mthp) for 2'-protection and a phosphoramidite coupling procedure.
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ISSN:0261-3166