Digitoxin elimination in healthy subjects taking ampicillin

The present study was carried out to evaluate the changes in digitoxin kinetics during ampicillin administration. Subjects were informed of the nature of the study and the treatment was applied to those who gave their written consent. Six healthy volunteers received a single oral dose of 1.0 mg of d...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of clinical pharmacology research Vol. 7; no. 1; p. 33
Main Authors Lucena, M I, Moreno, A, Fernandez, M C, Garcia-Morillas, M, Andrade, R
Format Journal Article
LanguageEnglish
Published Switzerland 1987
Subjects
Adult
Ampicillin - adverse effects
Ampicillin - blood
Digitoxin - urine
Digoxin - blood
Drug Interactions
Female
Half-Life
Humans
Kinetics
Male
Online AccessGet more information
ISSN0251-1649

Cover

More Information
Summary:The present study was carried out to evaluate the changes in digitoxin kinetics during ampicillin administration. Subjects were informed of the nature of the study and the treatment was applied to those who gave their written consent. Six healthy volunteers received a single oral dose of 1.0 mg of digitoxin. Three days later, they were given orally ampicillin trihydrate, 500 mg four times daily, for five consecutive days. Blood samples were taken at 24, 36, 48, 60, 72, 96, 120, 144, 168 and 192 hours after digitoxin. Compliance with ampicillin regimen was verified by fluorimetric measurement of serum ampicillin. Concentrations of serum digitoxin were determined by radioimmunoassay. The mean digitoxin elimination half-life changed from 162.8 +/- 12.9 h before to 181.3 +/- 10.1 h (mean +/- s.e. mean) after ampicillin. These differences were not significant. No consistent evidence of a kinetic interaction between digitoxin and the broad-spectrum antibiotic ampicillin was found.
ISSN:0251-1649